Pr Stefan TRAPP
Professor of Autonomic Neuroscience and Metabolic Disease, Director of the Centre for Cardiovascular and Metabolic Neuroscience, University College London
Titre : Glucagon-like Peptide-1 (GLP-1) produced in the brain: its function and importance.
Date : Jeudi 3 octobre 2019, à 12h
Lieu : Salle des séminaires de l’Institut Jacques Monod, Bâtiment Buffon, 15 rue Hélène Brion, pièce RdC bas 18B, Université Paris Diderot, campus PRG
Invité par : Dr Hirac Gurden, Equipe Régulation de la Glycémie par le Système Nerveux Central
Glucagon-like Peptide-1 (GLP-1) produced in the brain: its function and importance
GLP-1 is an incretin, released by the gut to regulate insulin secretion, but is also produced in the brain and affects food intake. Our lab uses mouse models combined with chemogenetic viral targeting to investigate the precise function of GLP-1 producing preproglucagon (PPG) neurons in the brain and this seminar discusses in detail their neuroanatomical and functional properties. Our data suggests that PPG neurons form part of a secondary satiation/satiety circuit, activated by both psychogenic stress and presumptive gastric distension from abnormally large meals. The capacity of PPG neurons to substantially reduce food intake renders them an attractive target for weight-loss drugs separate to the manipulation of pathways affecting day-to-day intake.