Régulation de la Glycémie par le Système Nerveux Central

 

Sélection de publications

1/ Bellini L, Campana M, Rouch C, Chacinska M, Bugliani M, Meneyrol K, Hainault I, Lenoir V, Denom J, Véret J, Kassis N, Thorens B, Ibberson M, Marchetti P, Blachnio-Zabielska A, Cruciani-Guglielmacci C, Prip-Buus C, Magnan C, Le Stunff H. Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets. Diabetologia. 2018 May 12.

2/ Wigger L, Cruciani-Guglielmacci C, Nicolas A, Denom J, Fernandez N, Fumeron F, Marques-Vidal P, Ktorza A, Kramer W, Schulte A, Le Stunff H, Liechti R, Xenarios I, Vollenweider P, Waeber G, Uphues I, Roussel R, Magnan C, Ibberson M, Thorens B. Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans. Cell Rep. 2017 Feb 28;18(9):2269-2279.

3/ Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M. Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.  Mol Metab. 2017 Jan 26;6(4):340-351.

4/ Karaca M, Frigerio F, Migrenne S, Martin-Levilain J, Skytt DM, Pajecka K, Martin-del-Rio R, Gruetter R, Tamarit-Rodriguez J, Waagepetersen HS, Magnan C, Maechler P. Lack of GDH-dependent glutamate oxidation in the brain leads to central energy deficiency reshaping peripheral energy distribution. Cell Rep. 2015 Oct 13 ;13(2):365-75.

5/ Picard A, Moullé VS, Le Foll C, Cansell C, Véret J, Coant N, Le Stunff H, Migrenne S, Luquet S, Cruciani-Guglielmacci C, Levin BE, Magnan C. Physiological and pathophysiological implications of lipid sensing in the brain. Diabetes Obes Metab. 2014 Sep;16 Suppl 1:49-55. (Abstract)

 

Publications indexées dans PubMed (depuis 2014)

González-García I, Contreras C, Estévez-Salguero Á, Ruíz-Pino F, Colsh B, Pensado I, Liñares-Pose L, Rial-Pensado E, Martínez de Morentin PB, Fernø J, Diéguez C, Nogueiras R, Le Stunff H, Magnan C, Tena-Sempere M, López M. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell Rep. 2018 Oct 9;25(2):413-423.e5.

Baloula V, Fructuoso M, Kassis N, Gueddouri D, Paul JL, Janel N. Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia. Redox Biol. 2018 Oct;19:200-209.

London J, Ndiaye FK, Bui LC, Souchet B, Daubigney F, Magnan C, Luquet S, Dairou J, Janel N, Rouch C. Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain. Mol Neurobiol. 2018 Sep 20.

Charpentier J, Waget A, Klopp P, Magnan C, Cruciani-Guglielmacci C, Lee SJ, Burcelin R, Grasset E. Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice. Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G671-G684.

Bandet CL, Mahfouz R, Véret J, Sotiropoulos A, Poirier M, Giussani P, Campana M, Philippe E, Blachnio-Zabielska A, Ballaire R, Le Liepvre X, Bourron O, Berkeš  D, Górski J, Ferré P, Le Stunff H, Foufelle F, Hajduch E. Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions. Diabetes. 2018 Jul;67(7):1258-1271.

Latour A, Gu Y, Kassis N, Daubigney F, Colin C, Gausserès B, Middendorp S, Paul JL, Hindié V, Rain JC, Delabar JM, Yu E, Arbones M, Mallat M, Janel N. LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice. Mol Neurobiol. 2018 May 30.

Montana L, Lamon M, Barrat C, Hansel B, Magnan C, Arapis K. Correction to: Establishing a Reproducible Murine Animal Model of Single Anastomosis Duodenoileal Bypass with Sleeve Gastrectomy (SADl-S). Obes Surg. 2018 May 15.

Bellini L, Campana M, Rouch C, Chacinska M, Bugliani M, Meneyrol K, Hainault I, Lenoir V, Denom J, Véret J, Kassis N, Thorens B, Ibberson M, Marchetti P, Blachnio-Zabielska A, Cruciani-Guglielmacci C, Prip-Buus C, Magnan C, Le Stunff H. Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets. Diabetologia. 2018 May 12.

Hoyles L, Jiménez-Pranteda ML, Chilloux J, Brial F, Myridakis A, Aranias T, Magnan C, Gibson GR, Sanderson JD, Nicholson JK, Gauguier D, McCartney AL, Dumas  ME. Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota. Microbiome. 2018 Apr 20;6(1):73.

Laperrousaz E, Denis RG, Kassis N, Contreras C, López M, Luquet S, Cruciani-Guglielmacci C, Magnan C. Lipoprotein Lipase Expression in Hypothalamus Is Involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure. Front Endocrinol (Lausanne). 2018 Mar 14;9:103.

Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M. Corrigendum to « Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome » [Free Radic. Biol. Med. 114 (2018) 122-130]. Free Radic Biol Med. 2018 Apr;118:150.

Le Marec A, Sungeelee S, Zeghouani A, Gonzalez L, Le Stunff H. [Role of ceramide metabolism in adipose browning: impact on energy homeostasis in obesity]. Med Sci (Paris). 2018 Feb;34(2):132-135.

Campana M, Bellini L, Rouch C, Rachdi L, Coant N, Butin N, Bandet CL, Philippe E, Meneyrol K, Kassis N, Dairou J, Hajduch E, Colsch B, Magnan C, Le Stunff H. Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Mol Metab. 2018 Feb;8:23-36.

London J, Rouch C, Bui LC, Assayag E, Souchet B, Daubigney F, Medjaoui H, Luquet S, Magnan C, Delabar JM, Dairou J, Janel N. Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues. Mol Neurobiol. 2018 May;55(5):3822-3831.

Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M. Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome. Free Radic Biol Med. 2018 Jan;114:122-130.

Pénicaud L, Magnan C. Physiology and biochemistry of type 2 diabetes: A tribute to Dr Alain Ktorza. Biochimie. 2017 Dec;143:1-2.

Cruciani-Guglielmacci C, Magnan C. Brain lipoprotein lipase as a regulator of energy balance. Biochimie. 2017 Dec;143:51-55.

Cruciani-Guglielmacci C, López M, Campana M, le Stunff H. Brain Ceramide Metabolism in the Control of Energy Balance. Front Physiol. 2017 Oct 12;8:787.Review.

Gao Y, Layritz C, Legutko B, Eichmann TO, Laperrousaz E, Moullé VS, Cruciani-Guglielmacci C, Magnan C, Luquet S, Woods SC, Eckel RH, Yi CX, Garcia-Caceres C, Tschöp MH. Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity. Diabetes. 2017 Oct;66(10):2555-2563.

Rijnsburger M, Eggels L, Castel J, Cruciani-Guglielmacci C, Ackermans MT, Luquet S, la Fleur SE. A novel, double intra-carotid cannulation technique to study the effect of central nutrient sensing on glucose metabolism in the rat. J  Neurosci Methods. 2017 Oct 1;290:79-84.

Lerat H, Imache MR, Polyte J, Gaudin A, Mercey M, Donati F, Baudesson C, Higgs MR, Picard A, Magnan C, Foufelle F, Pawlotsky JM. Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice. J Biol Chem. 2017 Aug 4;292(31):12860-12873.

Laperrousaz E, Moullé VS, Denis RG, Kassis N, Berland C, Colsch B, Fioramonti X, Philippe E, Lacombe A, Vanacker C, Butin N, Bruce KD, Wang H, Wang Y, Gao Y, Garcia-Caceres C, Prévot V, Tschöp MH, Eckel RH, Le Stunff H, Luquet S, Magnan C, Cruciani-Guglielmacci C. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia. 2017 Jul;60(7):1314-1324.

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M. Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion. Mol Metab. 2017 Jan 26;6(4):340-351.

da Silva Xavier G, Mondragon A, Mourougavelou V, Cruciani-Guglielmacci C, Denom J, Herrera PL, Magnan C, Rutter GA. Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice. Diabetologia. 2017 Jun;60(6):1043-1050.

Tammaro P, Hansel B, Police A, Kousouri M, Magnan C, Marmuse JP, Arapis K. Laparoscopic Adjustable Gastric Banding: Predictive Factors for Weight Loss and Band Removal After More than 10 Years’ Follow-Up in a Single University Unit. World J Surg. 2017 Aug;41(8):2078-2086.

Wigger L, Cruciani-Guglielmacci C, Nicolas A, Denom J, Fernandez N, Fumeron F, Marques-Vidal P, Ktorza A, Kramer W, Schulte A, Le Stunff H, Liechti R, Xenarios I, Vollenweider P, Waeber G, Uphues I, Roussel R, Magnan C, Ibberson M, Thorens B. Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans. Cell Rep. 2017 Feb 28;18(9):2269-2279.

Arapis K, Tammaro P, Dorian S, Donatelli G, Pelletier AL, Dumont JL, Becheur H, Magnan C, Marmuse JP. Technical Aspects of Laparoscopic Janeway Gastrostomy : Is an Alternative Method Available to Access the Excluded Structures in Patients with Roux-en-Y Anatomy if Laparoscopy-Assisted Transgastric Endoscopic Retrograde Choledochopancreatoscopy is not Possible ? 2017 Mar;27(3):630-640

Chelminski Y, Magnan C, Luquet S, Everard A, Meunier N, Gurden H, Martin C. Odor-induced neuronal rhythms in the olfactory bulb are profoundly modified in ob/ob obese mice. Front Physiol. 2017 Jan 19;8:2.

Vauthier V, Roujeau C, Chen P, Sarkis C, Migrenne S, Hosoi T, Ozawa K, Rouillé Y, Foretz M, Mallet J, Launay JM, Magnan C, Jockers R, Julie Dam J. Endospanin 1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling. Mol Metab. Nov 3;6(1):159-172.

Pruvost R, Le Stunff H. [Sphingosine kinase-1 : role in non alcoholic fatty liver disease]. Med Sci (Paris). 2016 8-9 ;32(8-9):716-8.

Casteras S, Abdul-Wahed A, Soty M, Vulin F, Guillou H, Campana M, Le Stunff H, Irola L, Rajas F, Mithieux G, Gautier-Stein A. The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice. Diabetologia. 2016 Sep 9.

Arapis K, Tammaro P, Parenti LR, Pelletier AL, Chosidow D, Kousouri M, Magnan C, Hansel B, Marmuse JP. Long-Term Results After Laparoscopic Adjustable Gastric Banding for Morbid Obesity : 18-Year Follow-Up in a Single University Unit. Obes Surg. 2016 Jul 22.

Solomou A, Philippe E, Chabosseau P, Migrenne-Li S, Gaitan J, Lang J, Magnan C, Rutter GA. Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia. Nutr Metab (Lond). 2016 Jul 7 ;13:46.

Semplici F, Mondragon A, Macintyre B, Madeyski-Bengston K, Persson-Kry A, Johanson S, Ramne A, Marley A, McGinty J, French P, Gaitan J, Lang J, Migrenne-Li S, Philippe E, Herrera PL, Magnan C, da Silva Xavier G, Rutter GA. Cell type-specific deletion reveals roles for Per-Arnt-Sim (PAS) kinase in insulin and glucagon production. Diabetologia. 2016 Sep ;59(9):1938-47.

Berland C, Cansell C, Hnasko T, Magnan C, Luquet S. Dietary triglycerides as signaling molecules that influence reward and motivation. Curr Opin Behav Sci. 2016 Jun;9:126-135.

Delarue J, Allain-Jeannic G, Guillerm S, Cruciani-Guglielmacci C, Magnan C, Moineau MP, Le Guen C. Interaction of low dose of fish oil and glucocorticoids on insulin sensitivity and lipolysis in healthy humans : a randomized controlled study. Mol Nutr Food Res 2016 Apr ;60(4):886-96.

Marmugi A, Parnis J, Chen X, Carmichael L, Hardy J, Mannan N, Marchetti P, Piemonti L, Bosco D, Johnson P, Shapiro JA, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Thorens B, Valdivia HH, Rutter GA, Leclerc I. Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores. Diabetes. 2016 Apr ;65(4):1009-21.

Magnan C, Levin BE, Luquet S. Brain lipid sensing and the neural control of energy balance. Mol Cell Endocrinol. 2015 Dec 15 ;418 Pt 1:3-8.

Lovera-Leroux M, Crobeddu B, Kassis N, Petit PX, Janel N, Baeza-Squiban A, Andreau K. The iron component of particulate matter is antiapoptotic : A clue to the development of lung cancer after exposure to atmospheric pollutants ? Biochimie. 2015 Nov ;118:195-206.

Magnan C, Luquet S. [Role of fatty acids in the nervous control of energy balance]. Biol Aujourdhui. 2015 ;209(4):309-15.

Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 2015 Oct 6 ;22(4):646-57.

Karaca M, Frigerio F, Migrenne S, Martin-Levilain J, Skytt DM, Pajecka K, Martin-del-Rio R, Gruetter R, Tamarit-Rodriguez J, Waagepetersen HS, Magnan C, Maechler P. Lack of GDH-dependent glutamate oxidation in the brain leads to central energy deficiency reshaping peripheral energy distribution. Cell Rep. 2015 Oct 13 ;13(2):365-75.

Solomou A, Meur G, Bellomo E, Hodson DJ, Tomas A, Migrenne-Li S, Philippe E, Herrera PL, Magnan C, Rutter GA. The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion. J Biol Chem. 2015 Aug 28 ;290(35):21432-42.

Dalmas E, Toubal A, Alzaid F, Blazek K, Eames HL, Lebozec K, Pini M, Hainault I, Montastier E, Denis RG, Ancel P, Lacombe A, Ling Y, Allatif O, Cruciani-Guglielmacci C, André S, Viguerie N, Poitou C, Stich V, Torcivia A, Foufelle F, Luquet S, Aron-Wisnewsky J, Langin D, Clément K, Udalova IA, Venteclef N. Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med. 2015 Jun ;21(6):610-8.

Taveaux C, Chollet C, Waeckel L, Desposito D, Bichet D, Arthus MF, Magnan C, Philippe E, Paradis V, Foufelle F, Hainault I, Enhornig S, Velho G, Roussel R, Bankir L, Mellander O, Bouby N. Vasopressin and hydratation play a major role in the development of glucose intolerance and hepatic steatosis in obese rats. Diabetologia. 2015 May ;58(5):1081-90.

Raoux M, Devin A, Vacher P, Gaitan J, Papin J, Picard A, Limon I, Kas M, Kostrzewa E, Magnan C, Lang J. Multilevel control of glucose homeostasis by adenylyl cyclase. Diabetologia. 2015 Apr ;58(4):749-57

Moullé VS, Picard A, Cansell C, Luquet S, Magnan C. [Role of brain lipid sensing in nervous regulation of energy balance]. Med Sci (Paris). 2015 Apr ;31(4):397-403.

Bellini L, Campana M, Mahfouz R, Carlier A, Véret J, Magnan C, Hajduch E, Le Stunff H. Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes. Expert Opin Ther Targets. 2015 ;19(8):1037-50.

Sun G, da Silva Xavier G, Gorman T, Priest C, Solomou A, Hodson DJ, Foretz M, Viollet B, Herrera PL, Parker H, Reimann F, Gribble FM, Migrenne S, Magnan C, Marley A, Rutter GA. LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Mol Metab. 2015 Jan 31 ;4(4):277-86.

Gjoni E, Cinque A, Coant N, Nurul Islam M, Ng Carl KY, Verderio C, Magnan C, Riboni L, Viani P, Le Stunff H, Giussani P. Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in Ins1 β cells. PLoS One. 2014 Oct 28 ;9(10):e110875.

Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, Dileone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014 Oct ;19(10):1095-105.

Picard A, Moullé VS, Le Foll C, Cansell C, Véret J, Coant N, Le Stunff H, Migrenne S, Luquet S, Cruciani-Guglielmacci C, Levin BE, Magnan C. Physiological and pathophysiological implcations of lipid sensing in the brain. Diabetes Obes Metab. 2014 Sep ;16 Suppl 1:49-55.

Véret J, Bellini L, Giussani P, Ng C, Magnan C, Le Stunff H. Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity. J Clin Med. 2014 Jun 20 ;3(2):646-62.

Lamy CM, Sanno H, Labouèbe G, Picard A, Magnan C, Chatton JY, Thorens B. Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion. Cell Metab. 2014 Mar 4 ;19(3):527-38.

Moullé VS, Picard A, Le Foll C, Levin BE, Magnan C. Lipid sensing in the brain and regulation of energy balance. Diabetes Metab. 2014 Feb ;40(1):29-33.

Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, Magnan C, Migrenne S, Cruciani-Guglielmacci C, Cohen-Tannoudji J. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. Endocrinology. 2014 Feb ;155(2):592-604.

Tarussio D, Metref S, Seyer P, Mounien L, Vallois D, Magnan C, Foretz M, Thorens B. Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis. J Clin Invest. 2014 Jan 2 ;124(1):413-24.