Équipe Physiologie de l’Axe Gonadotrope

Responsable : Joëlle Cohen-Tannoudji (PR P7)

Cinq publications récentes

1/ Pierre A, Racine C, Rey R, Fanchin R, Taieb J, Cohen-Tannoudji J, Carmillo P, Pepinsky B, Cate RL, di Clemente N. Most cleaved anti-Müllerian hormone binds its receptor in human follicular fluid, but little is competent in serum. J Clin Endocrinol Metab. 2016 Dec ;101(12):4618-4627. (Abstract)

2/ Lannes J, L’hôte D, Fernandez-Vega A, Garrel G, Laverrière JN, Cohen-Tannoudji J, Quérat B. A regulatory loop between miR-132 and miR-1 125b involved in gonadotrope cells desensitization to GnRH. Sci. Rep. 2016 Aug 19;6:31563. (Abstract) http://www.cnrs.fr/insb/recherche/parutions/articles2016/b-querat.html

3/ Garrel G, Racine C, L’Hôte D, Denoyelle C, Guigon CJ, di Clemente N, Cohen-Tannoudji J. Anti-Müllerian hormone: a new actor of sexual dimorphism in pituitary gonadotrope activity before puberty. Sci Rep. 2016 Mar 31;6:23790. (Abstract) http://www.sfendocrino.org/_newsletters/345.html

4/ François CM, Wargnier R, Petit F, Goulvent T, Rimokh R, Treilleux I, Ray-Coquard I, Zazzu V, Cohen-Tannoudji J, Guigon CJ. 17β-estradiol inhibits spreading of metastatic cells from granulosa cell tumors through a non-genomic mechanism involving GPER1. Carcinogenesis. 2015 May;36(5):564-73. (Abstract)

5/ Vandormael-Pournin S, Guigon CJ, Ishaq M, Coudouel N, Avé P, Huerre M, Magre S, Cohen-Tannoudji J, Cohen-Tannoudji M. Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells. Cell Death Differ. 2015 Jan;22(1):108-17. (Abstract) http://www.cnrs.fr/insb/recherche/parutions/articles2014/m-cohen.html

Publications indexées dans PubMed (depuis 2012)

Garrel G, Racine C, L’Hôte D, Denoyelle C, Guigon CJ, di Clemente N, Cohen-Tannoudji J. Anti-Müllerian hormone: a new actor of sexual dimorphism in pituitary gonadotrope activity before puberty. Sci Rep. 2016 Mar 31;6:23790.

Pierre A, Estienne A, Racine C, Picard JY, Fanchin R, Lahoz B, Alabart JL, Folch J, Jarrier P, Fabre S, Monniaux D, di Clemente N. The Bone Morphogenetic Protein 15 Up-Regulates the Anti-Müllerian Hormone Receptor Expression in Granulosa Cells. J Clin Endocrinol Metab. 2016 Jun;101(6):2602-11.

Lannes J, L’Hôte D, Fernandez-Vega A, Garrel G, Laverrière JN, Cohen-Tannoudji J, Quérat B. A regulatory loop between miR-132 and miR-1 125b involved in gonadotrope cells desensitization to GnRH. Sci. Rep. 2016 Aug 19;6:31563.

Laverrière JN, L’Hôte D, Tabouy L, Schang AL, Quérat B, Cohen-Tannoudji J. Epigenetic regulation of alternative promoters and enhancers in progenitor, immature, and mature gonadotrope cell lines. Mol Cell. Endocrinol. 2016 Oct;15;434:250-65.

Pierre A, Racine C, Rey R, Fanchin R, Taieb J, Cohen-Tannoudji J, Carmillo P, Pepinsky B, Cate RL, di Clemente N. Most cleaved anti-Müllerian hormone binds its receptor in human follicular fluid, but little is competent in serum. J Clin Endocr Metab. 2016 Sept 13.

Estienne A, Pierre A, di Clemente N, Picard JY, Jarrier P, Mansanet C, Monniaux D, Fabre S. Anti-Müllerian hormone regulation by the bone morphogenetic proteins in the sheep ovary: deciphering a direct regulatory pathway. Endocrinology. 2015 Jan;156(1):301-13.

Vandormael-Pournin S, Guigon CJ, Ishaq M, Coudouel N, Avé P, Huerre M, Magre S, Cohen-Tannoudji J, Cohen-Tannoudji M. Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells. Cell Death Differ. 2015 Jan;22(1):108-17.

Lannes J, L’Hôte D, Garrel G, Laverrière JN, Cohen-Tannoudji J, Quérat B. A MicroRNA-132/212 Pathway Mediates GnRH Activation of FSH Expression. Mol Endocrinol. 2015 Mar;29(3):364-72.

Palandri A, L’Hôte D, Cohen-Tannoudji J, Tricoire H, Monnier V. Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells. Hum Mol Genet. 2015 May 1;24(9):2615-26.

François CM, Wargnier R, Petit F, Goulvent T, Rimokh R, Treilleux I, Ray-Coquard I, Zazzu V, Cohen-Tannoudji J, Guigon CJ. 17β-estradiol inhibits spreading of metastatic cells from granulosa cell tumors through a non-genomic mechanism involving GPER1. Carcinogenesis. 2015 May;36(5):564-73.

Manna PR, Stetson CL, Daugherty C, Shimizu I, Syapin PJ, Garrel G, Cohen-Tannoudji J, Huhtaniemi I, Slominski AT, Pruitt K, Stocco DM. Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging. Mech Ageing Dev. 2015 Sep;150:74-82.

Hirschhorn T, di Clemente N, Amsalem AR, Pepinsky RB, Picard JY, Smorodinsky NI, Cate RL, Ehrlich M. Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II. J Cell Sci. 2015 Apr 1;128(7):1352-64.

Arouche N, Picard JY, Monniaux D, Jamin SP, Vigier B, Josso N, Cate RL, di Clemente N, Taieb J. The BOC ELISA, a ruminant-specific AMH immunoassay, improves the determination of plasma AMH concentration and its correlation with embryo production in cattle. Theriogenology. 2015 Nov;84(8):1397-404.

El Hadri K, Denoyelle C, Ravaux L, Viollet B, Foretz M, Friguet B, Rouis M, Raymondjean M. AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs. PLoS One. 2015 Jul 10;10(7):e0132498.

Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, Tsunekawa N, Ozawa A, Aiyama Y, Yoneda A, Suzuki H, Saito M, Picard JY, Kohno K, Kurohmaru M, Kanai-Azuma M, Kanai Y. A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads. Reproduction. 2014 Dec;148(6):H1-9.
Anttonen M, Pihlajoki M, Andersson N, Georges A, L’Hôte D, Vattulainen S, Färkkilä A, Unkila-Kallio L, Veitia RA, Heikinheimo M. FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells. PLoS One. 2014 Jan 9;9(1):e85545.

Georges A, L’Hôte D, Todeschini AL, Auguste A, Legois B, Zider A, Veitia RA. The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells. eLife. 2014 Nov 4;3.

Pasquier J, Lafont AG, Rousseau K, Quérat B, Chemineau P, Dufour S. Looking for the bird Kiss: evolutionary scenario in sauropsids. BMC Evol Biol. 2014 Feb 19;14(1):30.

Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, Magnan C, Migrenne S, Cruciani-Guglielmacci C, Cohen-Tannoudji J. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. Endocrinology. 2014 Feb;155(2):592-604.

Maugars G, Dufour S, Cohen-Tannoudji J, Quérat B. Multiple thyrotropin β-subunit and thyrotropin receptor-related genes arose during vertebrate evolution. PLoS One. 2014 Nov 11;9(11):e111361.

Benayoun BA, Anttonen M, L’Hôte D, Bailly-Bechet M, Andersson N, HeikinheimoM, Veitia RA. Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation. Oncogene. 2013 May 30;32(22):2739-46.

Schang AL, Bleux C, Chenut MC, Ngô-Muller V, Quérat B, Jeanny JC, Counis R, Cohen-Tannoudji J, Laverrière JN. Identification and analysis of two novel sites of rat GnRH receptor gene promoter activity: the pineal gland and retina. Neuroendocrinology. 2013;97(2):115-31.

Schang AL, Granger A, Quérat B, Bleux C, Cohen-Tannoudji J, Laverrière JN. GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene. Mol Endocrinol. 2013 Jan;27(1):74-91.

Avet C, Garrel G, Denoyelle C, Laverrière JN, Counis R, Cohen-Tannoudji J, Simon V. SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells. J Biol Chem. 2013 Jan 25;288(4):2641-54.

Manna PR, Cohen-Tannoudji J, Counis R, Garner CW, Huhtaniemi I, Kraemer FB, Stocco DM. Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. J Biol Chem. 2013 Mar 22;288(12):8505-18.

Ishaq M, Schang AL, Magre S, Laverrière JN, Guillou A, Coudouel N, Wargnier R, Cohen-Tannoudji J, Counis R. Rat Gnrhr promoter directs species-specific gene expression in the pituitary and testes of transgenic mice. J Mol Endocrinol. 2013 Apr 23;50(3):411-26.

Maione L, Albarel F, Bouchard P, Gallant M, Flanagan CA, Bobe R, Cohen-Tannoudji J, Pivonello R, Colao A, Brue T, Millar RP, Lombes M, Young J, Guiochon-Mantel A, Bouligand J. R31C GNRH1 mutation and congenital hypogonadotropic hypogonadism. PLoS One. 2013 Jul 25;8(7):e69616. Print 2013. Erratum in: PLoS One. 2013;8(8).

Cohen-Tannoudji J, Avet C, Garrel G, Counis R, Simon V. Decoding high gonadotropin-releasing hormone pulsatility: a role for GnRH receptor coupling to the cAMP pathway? Front Endocrinol (Lausanne). 2012, 3(107), 1-6.

Magre S, Rebourcet D, Ishaq M, Wargnier R, Debard C, Vidal H, Cohen-Tannoudji J, Le Magueresse B. Gender differences in transcriptional signature of developing rat testes and ovaries following embryonic exposure to 2,3,7,8-TCDD, PLoS ONE. 2012, 7 (7), e40306.

Schang AL, Quérat B, Simon V, Garrel G, Bleux C, Counis R, Cohen-Tannoudji J, Laverrière JN. Mechanisms underlying the tissue-specific and regulated activity of the Gnrhr promoter in mammals. Front Endocrinol (Lausanne), 2012 Dec 13;3:162.

Simon V, Oner S, Cohen-Tannoudji J, Tobin AB, Lanier SM. Influence of the accessory protein SET on M3 muscarinic receptor Phosphorylation and G protein coupling. Mol Pharmacol 2012, 82 (1),17-26.

Kim WG, Guigon CJ, Fozzatti, L Park, JW Lu C, Willingham MC, Cheng SY. SKI-606, a Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer. Clin Cancer Res 2012, 18 (5), 1281-90.

Etudes cliniques (INSERM U1133)

Bénard J, Duros S, Hachem HE, Sonigo C, Sifer C, Grynberg M. Freezing oocytes or embryos after controlled ovarian hyperstimulation in cancer patients: the state of the art. Future Oncol. 2016 May 17.

Sonigo C, Simon C, Boubaya M, Benoit A, Sifer C, Sermondade N, Grynberg M. What threshold values of antral follicle count and serum AMH levels should be considered for oocyte cryopreservation after in vitro maturation? Hum Reprod. 2016 Jul;31(7):1493-500.

Bénard J, Calvo J, Comtet M, Benoit A, Sifer C, Grynberg M. [Fertility preservation in women of the childbearing age: Indications and strategies]. J Gynecol Obstet Biol Reprod (Paris). 2016 May;45(5):424-44. Review. French.

Sarandi S, Herbemont C, Sermondade N, Benoit A, Sonigo C, Poncelet C, Benard J, Gronier H, Boujenah J, Grynberg M, Sifer C. [A prospective study to compare the efficiency of oocyte vitrification using closed or open devices]. Gynecol Obstet Fertil. 2016 May;44(5):280-4. French.

Sonigo C, Seroka A, Cédrin-Durnerin I, Sermondade N, Sifer C, Grynberg M. History of ABVD alters the number of oocytes vitrified after in vitro maturation in fertility preservation candidates. Future Oncol. 2016 Mar 10.

Valdelièvre C, Sonigo C, Comtet M, Simon C, Eskenazi S, Grynberg M. [Impact of gonadotropins in women suffering from cancer]. Bull Cancer. 2016 Mar;103(3):282-8. Review. French.

Durand M, Sermondade N, Herbemont C, Benard J, Gronier H, Boujenah J, Cédrin-Durnerin I, Poncelet C, Grynberg M, Sifer C. [Embryo development in two single-step media: Analysis of 2059 sibling oocytes]. Gynecol Obstet Fertil. 2016 Mar;44(3):163-7. French.

Grynberg M, Poulain M, le Parco S, Sifer C, Fanchin R, Frydman N. Similar in vitro maturation rates of oocytes retrieved during the follicular or luteal phase offer flexible options for urgent fertility preservation in breast cancer patients. Hum Reprod. 2016 Mar;31(3):623-9.

Frydman R, Grynberg M. Introduction: Male fertility preservation: innovations and questions. Fertil Steril. 2016 Feb;105(2):247-8.

Grynberg M, Bidet M, Benard J, Poulain M, Sonigo C, Cédrin-Durnerin I, Polak M. Fertility preservation in Turner syndrome. Fertil Steril. 2016 Jan;105(1):13-9.

Grynberg M, Benard J. [Fertility preservation and endometriosis: When medical borders on social]. Gynecol Obstet Fertil. 2015 Dec;43(12):759-60. French.

Comtet M, Sonigo C, Valdelièvre C, Sermondade N, Sifer C, Grynberg M. [Fertility preservation in breast cancer patients: the state of art in 2014?]. Bull Cancer. 2015 May;102(5):443-53. Review. French.

Sonigo C, Sermondade N, Benard J, Benoit A, Shore J, Sifer C, Grynberg M. The past, present and future of fertility preservation in cancer patients. Future Oncol. 2015 Sep 11.

Sebag-Peyrelevade S, El Hachem H, Gallot V, Genro VK, Fanchin R. [The influence of exogenous LH/hCG activity on serum progesterone levels on the day of hCG administration in in vitro fertilization]. J Gynecol Obstet Biol Reprod (Paris). 2015 Jun;44(6):524-31. French.

Dupont C, Hafhouf E, Sermondade N, Sellam O, Herbemont C, Boujenah J, Faure C, Levy R, Poncelet C, Hugues JN, Cedrin-Durnerin I, Sonigo C, Grynberg M, Sifer C. Delivery rates after elective single cryopreserved embryo transfer related to embryo survival. Eur J Obstet Gynecol Reprod Biol. 2015 Feb 26;188:6-11.

Grynberg M. A plea for female fertility preservation. Future Oncol. 2014 Nov;10(14):2107-10.

El Hachem H, Atallah D, Grynberg M. Fertility preservation in breast cancer patients. Future Oncol. 2014 Aug;10(10):1767-77.

Sifer C, Herbemont C, Adda-Herzog E, Sermondade N, Dupont C, Cedrin-Durnerin I, Poncelet C, Levy R, Grynberg M, Hugues JN. Clinical predictive criteria associated with live birth following elective single embryo transfer. Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:229-32.

Sifer C, Khattabi LE, Dupont C, Sermondade N, Herbemont C, Porcher R, Cedrin-Durnerin I, Faure C, Lévy R, Grynberg M, Poncelet C, Hugues JN. Could sperm grade under high magnification condition predict IMSI clinical outcome? Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:189-94.

Foix-L’Hélias L, Grynberg M, Ducot B, Frydman N, Kerbrat V, Bouyer J, Labrune P. Growth development of French children born after in vitro maturation. PLoS One. 2014 Feb 26;9(2):e89713.

Hachem HE, Poulain M, Höher M, Fanchin R, Frydman R, Grynberg M. Serous adenocarcinoma of the ovary diagnosed during ultrasound evaluation for fertility preservation. Future Oncol. 2014 Oct;10(12):1907-12.

Legendre G, Moulin J, Vialard J, Ziegler DD, Fanchin R, Pouly JL, Watrelot A, Belaisch Allart J, Massin N, Fernandez H. Proximal occlusion of hydrosalpinges by Essure(®) before assisted reproduction techniques: a French survey. Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:300-4.

Trèves R, Grynberg M, Parco Sl, Finet A, Poulain M, Fanchin R. Female fertility preservation in cancer patients: an instrumental tool for the envisioning a postdisease life. Future Oncol. 2014 May;10(6):969-74.

Poulain M, Hesters L, Sanglier T, de Bantel A, Fanchin R, Frydman N, Grynberg M. Is it acceptable to destroy or include human embryos before day 5 in research programmes? Reprod Biomed Online. 2014 Apr;28(4):522-9.

El Hachem H, Poulain M, Finet A, Fanchin R, Frydman N, Grynberg MH. Live birth after frozen-thawed oocytes matured in vitro in a PCOS patient: a model for improving implantation rates in IVM cycles and objectively assessing the real potential of development of frozen oocytes matured in vitro. Gynecol Endocrinol. 2014 Jun;30(6):415-8.

Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA. The physiology and clinical utility of anti-Mullerian hormone in women. Hum Reprod Update. 2014 May-Jun;20(3):370-85.

Steffann J, Gigarel N, Samuels DC, Monnot S, Borghese R, Hesters L, Frydman N, Burlet P, Frydman R, Benachi A, Rotig A, Munnich A, Bonnefont JP. Data from artificial models of mitochondrial DNA disorders are not always applicable to humans. Cell Rep. 2014 May 22;7(4):933-4.