Equipe Contrôle Central du Comportement Alimentaire et de la Dépense Energétique (C2OFFEE)

Responsable : Serge Luquet (DR2, CNRS)

Cinq publications récentes

1) Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 2015 Oct 6;22(4):646-57. (Abstract)

2) Dalmas E, Toubal A, Alzaid F, Blazek K, Eames HL, Lebozec K, Pini M, Hainault I, Montastier E, Denis RG, Ancel P, Lacombe A, Ling Y, Allatif O, Cruciani-Guglielmacci C, André S, Viguerie N, Poitou C, Stich V, Torcivia A, Foufelle F, Luquet S, Aron-Wisnewsky J, Langin D, Clément K, Udalova IA, Venteclef N. Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med. 2015 Jun;21(6):610-8. (Abstract)

3) Geurts L, Everard A, Van Hul M, Essaghir A, Duparc T, Matamoros S, Plovier H, Castel J, Denis RG, Bergiers M, Druart C, Alhouayek M, Delzenne NM, Muccioli GG, Demoulin JB, Luquet S, Cani PD. Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. Nat Commun. 2015 Mar 11;6:6495. (Abstract)

4) Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014 Oct;19(10):1095-105. (Abstract) (Communiqué de presse CNRS)(Communiqué de presse de l’Université Paris Diderot Paris 7)(Autre communiqués)(https://destinationsante.com/le-gras-drogue-dure-pour-le-cerveau.html)

5) Joly-Amado A, Denis RG, Castel J, Lacombe A, Cansell C, Rouch C, Kassis N, Dairou J, Cani PD, Ventura-Clapier R, Prola A, Flamment M, Foufelle F, Magnan C, Luquet S. Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning. EMBO J. 2012 Nov 14;31(22):4276-88. (Abstract) Communiqué de presse EMBO Communiqué de presse du CNRS Communiqué de presse de l’Université Paris Diderot Paris 7.

Publications indexées dans Pubmed (depuis 2012)

Chelminski Y, Magnan C, Luquet S, Everard A, Meunier N, Gurden H, Martin C. Odor-induced neuronal rhythms in the olfactory bulb are profoundly modified in ob/ob obese mice. Front Physiol. In Press.

Le Thuc O, Cansell C, Bourourou M, Denis RG, Stobbe K, Devaux N, Guyon A, Cazareth J, Heurteaux C, Rostène W, Luquet S, Blondeau N, Nahon JL, Rovère C. Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation. EMBO Rep. 2016 Dec;17(12):1738-1752.

Martinerie C, Garcia M, Do TT, Antoine B, Moldes M, Dorothee G, Kazazian C, Auclair M, Buyse M, Ledent T, Marchal PO, Fesatidou M, Beisseiche A, Koseki H, Hiraoka S, Chadjichristos CE, Blondeau B, Denis RG, Luquet S, Fève B. NOV/CCN3 : A New Adipocytokine Involved in Obesity-Associated Insulin Resistance. Diabetes. 2016 Sep ;65(9):2502-15.

García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 2016 Aug 11 ;166(4):867-80.

Vavrova E, Lenoir V, Alves-Guerra MC, Denis RG, Castel J, Esnous C, Dyck JR, Luquet S, Metzger D, Bouillaud F, Prip-Buus C. Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance. Am J Physiol Endocrinol Metab. 2016 Sep 1;311(3):E649-60.

Leishman E, Mackie K, Luquet S, Bradshaw HB. Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. Biochim Biophys Acta. 2016 Jun ;1861(6):491-500.

Cansell C, Luquet S. Triglyceride sensing in the reward circuitry : A new insight in feeding behaviour regulation. Biochimie. 2016 Jan ;120:75-80.

Magnan C, Levin BE, Luquet S. Brain lipid sensing and the neural control of energy balance. Mol Cell Endocrinol. 2015 Dec 15 ;418 Pt 1:3-8.

Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 2015 Oct 6 ;22(4):646-57.

Dalmas E, Toubal A, Alzaid F, Blazek K, Eames HL, Lebozec K, Pini M, Hainault I, Montastier E, Denis RG, Ancel P, Lacombe A, Ling Y, Allatif O, Cruciani-Guglielmacci C, André S, Viguerie N, Poitou C, Stich V, Torcivia A, Foufelle F, Luquet S, Aron-Wisnewsky J, Langin D, Clément K, Udalova IA, Venteclef N. Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med. 2015 Jun ;21(6):610-8.

Moullé VS, Picard A, Cansell C, Luquet S, Magnan C. [Role of brain lipid sensing in nervous regulation of energy balance]. Med Sci (Paris). 2015 Apr ;31(4):397-403.

Geurts L, Everard A, Van Hul M, Essaghir A, Duparc T, Matamoros S, Plovier H, Castel J, Denis RG, Bergiers M, Druart C, Alhouayek M, Delzenne NM, Muccioli GG, Demoulin JB, Luquet S, Cani PD. Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. Nat Commun. 2015 Mar 11 ;6:6495.

Magnan C, Luquet S. [Role of fatty acids in the nervous control of energy balance]. Biol Aujourdhui. 2015 ;209(4):309-15. French.

Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. Nat Commun. 2014 Dec 5 ;5:5648.

Joly-Amado A, Cansell C, Denis RG, Delbes AS, Castel J, Martinez S, Luquet S. The hypothalamic arcuate nucleus and the control of peripheral substrates. Best Pract Res Clin Endocrinol Metab. 2014 Oct ;28(5):725-37.

Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014 Oct ;19(10):1095-105.

Picard A, Moullé VS, Le Foll C, Cansell C, Véret J, Coant N, Le Stunff H, Migrenne S, Luquet S, Cruciani-Guglielmacci C, Levin BE, Magnan C. Physiological and pathophysiological implications of lipid sensing in the brain. Diabetes Obes Metab. 2014 Sep ;16 Suppl 1:49-55.

Tavernier A, Cavin JB, Le Gall M, Ducroc R, Denis RG, Cluzeaud F, Guilmeau S, Sakar Y, Barbot L, Kapel N, Le Beyec J, Joly F, Chua S, Luquet S, Bado A. Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice. FASEB J. 2014 Sep ;28(9):4100-10.

Mouisel E, Relizani K, Mille-Hamard L, Denis R, Hourdé C, Agbulut O, Patel K, Arandel L, Morales-Gonzalez S, Vignaud A, Garcia L, Ferry A, Luquet S, Billat V, Ventura-Clapier R, Schuelke M, Amthor H. Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 15 ;307(4):R444-54.

Denis RG, Joly-Amado A, Cansell C, Castel J, Martinez S, Delbes AS, Luquet S. Central orchestration of peripheral nutrient partitioning and substrate utilization : implications for the metabolic syndrome. Diabetes Metab. 2014 Jun ;40(3):191-7.

Beranger GE, Pisani DF, Castel J, Djedaini M, Battaglia S, Amiaud J,Boukhechba F, Ailhaud G, Michiels JF, Heymann D, Luquet S, Amri EZ. Oxytocin reverses ovariectomy-induced osteopenia and body fat gain. Endocrinology. 2014. Apr ;155(4):1340-52.

Picard A, Rouch C, Kassis N, Moullé VS, Croizier S, Denis RG, Castel J, Coant N, Davis K, Clegg DJ, Benoit SC, Prévot V, Bouret S, Luquet S, Le Stunff H, Cruciani-Guglielmacci C, Magnan C. Hippocampal lipoprotein lipase regulates energy balance in rodents. Mol Metab. 2013 Nov 20;3(2):167-76.

Gao Y, Tschöp MH, Luquet S. Hypothalamic tanycytes : gatekeepers to metabolic control. Cell Metab. 2014 Feb 4 ;19(2):173-5.

Parnaudeau S, Dongelmans ML, Turiault M, Ambroggi F, Delbes AS, Cansell C, Luquet S, Piazza PV, Tronche F, Barik J. Glucocorticoid receptor gene inactivation in dopamine innervated areas selectively decreases behavioral responses to amphetamine. Front Behav Neurosci. 2014 Feb 12 ;8:35.

Lehti M, Donelan E, Abplanalp W, Al-Massadi O, Habegger KM, Weber J, Ress C, Mansfeld J, Somvanshi S, Trivedi C, Keuper M, Ograjsek T, Striese C, Cucuruz S, Pfluger PT, Krishna R, Gordon SM, Silva RA, Luquet S, Castel J, Martinez S, D’Alessio D, Davidson WS, Hofmann SM. High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. Circulation. 2013 Nov 26 ;128(22):2364-71.

Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V, Dehouck B. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab. 2013 Apr 2 ;17(4):607-17.

Rouger L, Denis GR, Luangsay S, Parmentier M. ChemR23 knockout mice display mild obesity but no deficit in adipocyte differentiation. J Endocrinol. 2013 Nov 7 ;219(3):279-89.

Joly-Amado A, Denis RG, Castel J, Lacombe A, Cansell C, Rouch C, Kassis N, Dairou J, Cani PD, Ventura-Clapier R, Prola A, Flamment M, Foufelle F, Magnan C, Luquet S. Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning. EMBO J. 2012 Nov 14 ;31(22):4276-88.

Cansell C, Denis RG, Joly-Amado A, Castel J, Luquet S. Arcuate AgRP neurons and the regulation of energy balance. Front Endocrinol (Lausanne). 2012 Dec 27 ;3:169.

Auffret J, Viengchareun S, Carré N, Denis RG, Magnan C, Marie PY, Muscat A,Fève B, Lombès M, Binart N. Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity. FASEB J. 2012 Sep ;26(9):3728-37.

Moullé VS, Cansell C, Luquet S, Cruciani-Guglielmacci C. The multiple roles of fatty acid handling proteins in brain. Front Physiol. 2012 Sep 28 ;3:385.

Cansell C, Luquet S. Hypothalamic regulation of energy balance : a key role for DICER miRNA processing in arcuate POMC neurons. Mol Metab. 2012 Dec 20 ;2(2):55-7.