Molecular and Cell Responses to Xenobiotics

 

Selected publications

1/ Xu X, Mathieu C, Berthelet J, Duval R, Bui LC, Busi F, Dupret JM, Rodrigues-Lima F. Human Arylamine N-Acetyltransferase 1 Is Inhibited by the Dithiocarbamate Pesticide Thiram. Mol Pharmacol. 2017 Sep;92(3):358-365.

2/ Mathieu C, Duval R, Cocaign A, Petit E, Bui LC, Haddad I, Vinh J, Etchebest C, Dupret JM, Rodrigues Lima F. An isozyme-specific redox switch in human brain glycogen phosphorylase modulates its allosteric activation by AMP. J Biol Chem. 2016 Sept 22. (Abstract) “Paper of the Week” of the Journal of Biological Chemistry

3/ Duval R, Xu X, Bui LC, Mathieu C, Petit E, Cariou K, Dodd RH, Dupret JM, Rodrigues-Lima F. Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens. Oncotarget. 2016 Feb 23;7(8):8688-99. (Abstract)

4/ George I, Naudin G, Boland S, Mornet S, Contremoulins V, Beugnon K, Martinon L, Lambert O, Baeza-Squiban A. Metallic oxide nanoparticle translocation across the human bronchial epithelial barrier. Nanoscale. 2015 Mar 14;7(10):4529-44. (Abstract)

5/ Guadagnini R, Moreau K, Hussain S, Marano F, Boland S. Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells. Nanotoxicology. 2015 May;9 Suppl 1:25-32. (Abstract)

Pubmed referenced publications (since 2014)

Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL, Lacout C, Cordonnier M, Rodrigues-Lima F, Chanteloup G, Mosca M, Chrétien ML, Bastie JN, Audia S, Sagot P, Ramla S, Martin L, Gleave M, Mezger V, Skoda R, Plo I, Garrido C, Girodon F, de Thonel A. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018 Apr 12;9(1):1431.

Neumann F, Gourdain S, Albac C, Dekker AD, Bui LC, Dairou J, Schmitz-Afonso I, Hue N, Rodrigues-Lima F, Delabar JM, Potier MC, Le Caër JP, Touboul D, Delatour B, Cariou K, Dodd RH. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859.

Puisney C, Baeza-Squiban A, Boland S. Mechanisms of Uptake and Translocation of Nanomaterials in the Lung. Adv Exp Med Biol. 2018;1048:21-36.

Marano F. Mieux prendre en compte la santé environnementale. Soins. 2018 Mar;63(823):50.

Busi F, Arluison V, Régnier P. Absolute Regulatory Small Noncoding RNA Concentration and Decay Rates Measurements in Escherichia coli. Methods Mol Biol. 2018;1737:231-248.

Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Alstrup Jensen K, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Teixeira JP, Tran CL, Cassee FR. Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge. Environ Health Perspect. 2017 Oct 10;125(10):106002.

Mousseau F, Puisney C, Mornet S, Borgne RL, Vacher A, Airiau M, Baeza-Squiban A, Berret JF. Supported pulmonary surfactant bilayers on silica nanoparticles: formulation, stability and impact on lung epithelial cells. Nanoscale. 2017 Oct 12;9(39):14967-14978.

Deweirdt J, Quignard JF, Crobeddu B, Baeza-Squiban A, Sciare J, Courtois A, Lacomme S, Gontier E, Muller B, Savineau JP, Marthan R, Guibert C, Baudrimont I. Involvement of oxidative stress and calcium signaling in airborne particulate matter – induced damages in human pulmonary artery endothelial cells. Toxicol In Vitro. 2017 Dec;45(Pt 3):340-350.

Crobeddu B, Aragao-Santiago L, Bui LC, Boland S, Baeza Squiban A. Oxidative potential of particulate matter 2.5 as predictive indicator of cellular stress. Environ Pollut. 2017 Nov;230:125-133.

Vranic S, Gosens I, Jacobsen NR, Jensen KA, Bokkers B, Kermanizadeh A, Stone V, Baeza-Squiban A, Cassee FR, Tran L, Boland S. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO(2) nanoparticles. Arch Toxicol. 2017 Jan;91(1):353-363.

García-Ramírez I, Tadros S, González-Herrero I, Martín-Lorenzo A, Rodríguez-Hernández G, Moore D, Ruiz-Roca L, Blanco O, Alonso-López D, Rivas JL, Hartert K, Duval R, Klinkebiel D, Bast M, Vose J, Lunning M, Fu K, Greiner T, Rodrigues-Lima F, Jiménez R, Criado FJG, Cenador MBG, Brindle P, Vicente-Dueñas C, Alizadeh A, Sánchez-García I, Green MR. Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice. Blood. 2017 May 11;129(19):2645-2656.

Simon V, Avet C, Grange-Messent V, Wargnier R, Denoyelle C, Pierre A, Dairou J, Dupret JM, Cohen-Tannoudji J. Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway. Endocrinology. 2017 Oct 1;158(10):3200-3211.

Xu X, Mathieu C, Berthelet J, Duval R, Bui LC, Busi F, Dupret JM, Rodrigues-Lima F. Human Arylamine N-Acetyltransferase 1 Is Inhibited by the Dithiocarbamate Pesticide Thiram. Mol Pharmacol. 2017 Sep;92(3):358-365.

Kubiak X, Duval R, Pluvinage B, Chaffotte AF, Dupret JM, Rodrigues-Lima F. Xenobiotic-metabolizing enzymes in Bacillus anthracis: molecular and functional analysis of a truncated arylamine N-acetyltransferase isozyme. Br J Pharmacol. 2017 Jul;174(14):2174-2182.

Mathieu C, Bui LC, Petit E, Haddad I, Agbulut O, Vinh J, Dupret JM, Rodrigues-Lima F. Molecular Mechanisms of Allosteric Inhibition of Brain Glycogen Phosphorylase by Neurotoxic Dithiocarbamate Chemicals. J Biol Chem. 2017 Feb 3;292(5):1603-1612.

Mathieu C, Dupret JM, Rodrigues Lima F. The structure of brain glycogen phosphorylase-from allosteric regulation mechanisms to clinical perspectives. FEBS J. 2017 Feb;284(4):546-554.

Delaval M, Wohlleben W, Landsiedel R, Baeza-Squiban A, Boland S. Assessment of the oxidative potential of nanoparticles by the cytochrome c assay: assay improvement and development of a high-throughput method to predict the toxicity of nanoparticles. Arch Toxicol. 2017 Jan;91(1):163-177.

Mathieu C, Duval R, Cocaign A, Petit E, Bui LC, Haddad I, Vinh J, Etchebest C, Dupret JM, Rodrigues Lima F. An isozyme-specific redox switch in human brain glycogen phosphorylase modulates its allosteric activation by AMP. J Biol Chem. 2016 Nov 11;291(46):23842-23853.

Mathieu C, de la Sierra-Gallay IL, Duval R, Xu X, Cocaign A, Léger T, Woffendin G, Camadro JM, Etchebest C, Haouz A, Dupret JM, Rodrigues-Lima F. Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE. J Biol Chem. 2016 Aug 26;291(35):18072-83.

Sirri V, Jourdan N, Hernandez-Verdun D, Roussel P. Sharing of mitotic pre-ribosomal particles between daughter cells. J Cell Sci. 2016 Apr 15;129(8):1592-604.

Duval R, Xu X, Bui LC, Mathieu C, Petit E, Cariou K, Dodd RH, Dupret JM, Rodrigues-Lima F. Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens. Oncotarget. 2016 Feb 23;7(8):8688-99.

Bui LC, Tomkiewicz C, Pierre S, Chevallier A, Barouki R, Coumoul X. Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration. Toxicol Sci. 2016 Jan;149(1):158-66.

Lovera-Leroux M, Crobeddu B, Kassis N, Petit PX, Janel N, Baeza-Squiban A, Andreau K. The iron component of particulate matter is antiapoptotic: A clue to the development of lung cancer after exposure to atmospheric pollutants? Biochimie. 2015 Nov;118:195-206.

Messaoudi N, Gautier V, Dairou J, Mihoub M, Lelandais G, Bouloc P, Landoulsi A, Richarme G. Fermentation and alternative respiration compensate for NADH dehydrogenase deficiency in a prokaryotic model of DJ-1-associated Parkinsonism. Microbiology. 2015 Nov;161(11):2220-31.

Gemble S, Ahuja A, Buhagiar-Labarchède G, Onclercq-Delic R, Dairou J, Biard DS, Lambert S, Lopes M, Amor-Guéret M. Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA. PLoS Genet. 2015 Jul 16;11(7):e1005384.

Mihoub M, Abdallah J, Gontero B, Dairou J, Richarme G. The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal. Biochem Biophys Res Commun. 2015 Aug 7;463(4):1305-10.

Duval R, Fritsch L, Bui LC, Berthelet J, Guidez F, Mathieu C, Dupret JM, Chomienne C, Ait-Si-Ali S, Rodrigues-Lima F. An acetyltransferase assay for CREB-binding protein based on reverse phase-ultra-fast liquid chromatography of fluorescent histone H3 peptides. Anal Biochem. 2015 Oct 1;486:35-7.

Chan Ho Tong L, Dairou J, Bui LC, Bouillon J, Rodrigues-Lima F, Dupret JM, Silar P. Screen for soil fungi highly resistant to dichloroaniline uncovers mostly Fusarium species. Fungal Genet Biol. 2015 Aug;81:82-7.

Duval R, Bui LC, Berthelet J, Dairou J, Mathieu C, Guidez F, Dupret JM, Cools J, Chomienne C, Rodrigues-Lima F. A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2). Sci Rep. 2015 Jun 4;5:10750.

Cowie H, Magdolenova Z, Saunders M, Drlickova M, Correia Carreira S, Halamoda Kenzaoi B, Gombau L, Guadagnini R, Lorenzo Y, Walker L, Fjellsbø LM, Huk A, Rinna A, Tran L, Volkovova K, Boland S, Juillerat-Jeanneret L, Marano F, Collins AR, Dusinska M. Suitability of human and mammalian cells of different origin for the assessment of genotoxicity of metal and polymeric engineered nanoparticles. Nanotoxicology. 2015 May;9 Suppl 1:57-65.

Lavelle C, Busi F, Arluison V. Multiple approaches for the investigation of bacterial small regulatory RNAs self-assembly. Methods Mol Biol. 2015;1297:21-42.

Dusinska M, Boland S, Saunder M, Juillerat-Jeannere L, Tran L, Pojana G, Marcomini A, Volkovova K, Tulinska J, Knudsen LE,Gombau L, Whelan M, Collins AR, Halamoda Kenzaoui B, Correia Carreira S,  Marano F, Housiadas C, Bilanicova D, Magdolenova Z, Fjellsbø LM,  Huk A, Handy R, Barancokova M, Bartonova A, Burello E, Walker L, Castell J, Cowie H,  Drlickova M, Fernandez B, Guadagnini R, Harris G, Harju M, Heimstad ES, Hurbankova M, Kazimirova A, Kovacikova Z, Kuricova M, Liskova A, Milcamps A, Mose T, Neubauerova E, Palosaari T, Pilou M, Poulsen MS, Ross B, Runden-Pran E, Sebekova K, Staruchova M, Vallotto D, Worth A. Towards an alternative testing strategy for nanomaterials used in nanomedicine: Lessons from NanoTEST. Nanotoxicology. 2015 9(S1): 118–132.

George I, Naudin G, Boland S, Mornet S, Contremoulins V, Beugnon K, Martinon L, Lambert O, Baeza-Squiban A. Metallic oxide nanoparticle translocation across the human bronchial epithelial barrier. Nanoscale. 2015 Mar 14;7(10):4529-44.

Xu X, Li de la Sierra-Gallay I, Kubiak X, Duval R, Chaffotte AF, Dupret JM, Haouz A, Rodrigues-Lima F. Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A. Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):266-73.

Delaval M, Boland S, Solhonne B, Nicola MA, Mornet S, Baeza-Squiban A, Sallenave JM, Garcia-Verdugo I. Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia. Part Fibre Toxicol. 2015 Jan 21;12:1.

Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A. Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. J Biol Chem. 2015 Jan 16;290(3):1885-97.

Cayrol B, Fortas E, Martret C, Cech G, Kloska A, Caulet S, Barbet M, Trépout S, Marco S, Taghbalout A, Busi F, Wegrzyn G, Arluison V. Riboregulation of the bacterial actin-homolog MreB by DsrA small noncoding RNA. Integr Biol (Camb). 2015 Jan;7(1):128-41.

Mathieu C, Duval R, Xu X, Rodrigues-Lima F, Dupret JM. Effects of pesticide chemicals on the activity of metabolic enzymes: focus on thiocarbamates. Expert Opin Drug Metab Toxicol. 2015 Jan;11(1):81-94.

Gesbert G, Ramond E, Tros F, Dairou J, Frapy E, Barel M, Charbit A. Importance of branched-chain amino acid utilization in Francisella intracellular adaptation. Infect Immun. 2015 Jan;83(1):173-83.

Juricek L, Bui LC, Busi F, Pierre S, Guyot E, Lamouri A, Dupret JM, Barouki R, Coumoul X, Rodrigues-Lima F. Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites. Arch Toxicol. 2015 Dec;89(12):2403-12.

George I, Vranic S, Boland S, Courtois A, Baeza-Squiban A. Development of an in vitro model of human bronchial epithelial barrier to study nanoparticle translocation. Toxicol In Vitro. 2015 Feb;29(1):51-8.

Guadagnini R, Moreau K, Hussain S, Marano F, Boland S. Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells. Nanotoxicology. 2015 May;9 Suppl 1:25-32.

Guadagnini R, Halamoda Kenzaoui B, Walker L, Pojana G, Magdolenova Z, Bilanicova D, Saunders M, Juillerat-Jeanneret L, Marcomini A, Huk A, Dusinska M, Fjellsbø LM, Marano F, Boland S. Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests. Nanotoxicology. 2015 May;9 Suppl 1:13-24.

Cocaign A, Kubiak X, Xu X, Garnier G, Li de la Sierra-Gallay I, Chi-Bui L, Dairou J, Busi F, Abuhammad A, Haouz A, Dupret JM, Herrmann JL, Rodrigues-Lima F. Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition. Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):3066-79.

Boland S, Hussain S, Baeza-Squiban A. Carbon black and titanium dioxide nanoparticles induce distinct molecular mechanisms of toxicity. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Nov-Dec;6(6):641-52.

Baeza-Squiban A. [Physio-pathological impacts of inhaled nanoparticles]. Biol Aujourdhui. 2014;208(2):151-8.

Goix S, Lévêque T, Xiong TT, Schreck E, Baeza-Squiban A, Geret F, Uzu G, Austruy A, Dumat C. Environmental and health impacts of fine and ultrafine metallic particles: assessment of threat scores. Environ Res. 2014 Aug;133:185-94.

Laurieri N, Dairou J, Egleton JE, Stanley LA, Russell AJ, Dupret JM, Sim E, Rodrigues-Lima F. From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. PLoS One. 2014 May 13;9(5):e96370.

Ponti D, Bellenchi GC, Puca R, Bastianelli D, Maroder M, Ragona G, Roussel P, Thiry M, Mercola D, Calogero A. The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis. PLoS One. 2014 May 1;9(5):e96037.

Hussain S, Garantziotis S, Rodrigues-Lima F, Dupret JM, Baeza-Squiban A, Boland S. Intracellular signal modulation by nanomaterials. Adv Exp Med Biol. 2014;811:111-34.

Ramond E, Gesbert G, Rigard M, Dairou J, Dupuis M, Dubail I, Meibom K, Henry T, Barel M, Charbit A. Glutamate utilization couples oxidative stress defense and the tricarboxylic acid cycle in Francisella phagosomal escape. PLoS Pathog. 2014 Jan;10(1):e1003893.

Bui LC, Tabouy L, Busi F, Dupret JM, Janel N, Planque C, Delabar JM, Rodrigues-Lima F, Dairou J. A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase. Anal Biochem. 2014 Mar 15;449:172-8.

Xu X, Kubiak X, Dupret JM, Rodrigues-Lima F. Arylamine N-acetyltransferases: a structural perspective. Comments regarding the BJP paper by Zhou et al., 2013. Br J Pharmacol. 2014 Jan;171(1):279-80.

Xu X, Mathieu C, Boitard SE, Dairou J, Dupret JM, Agbulut O, Rodrigues-Lima F. Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: molecular, cellular and kinetic aspects. FEBS Lett. 2014 Jan 3;588(1):138-42.

Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, Magnan C, Migrenne S, Cruciani-Guglielmacci C, Cohen-Tannoudji J. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. Endocrinology. 2014 Feb;155(2):592-604.

Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui LC, Bats AS, Fournet JC, Fernandez-Salguero P, Aggerbeck M, Lotersztajn S, Barouki R, Coumoul X. Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin. Toxicol Sci. 2014 Jan;137(1):114-24.

Medjkane S, Perichon M, Marsolier J, Dairou J, Weitzman JB. Theileria induces oxidative stress and HIF1α activation that are essential for host leukocyte transformation. Oncogene. 2014 Apr 3;33(14):1809-17.