Molecular and Cell Responses to Xenobiotics Team (RMCX)

Head: Jean-Marie Dupret (PR P7)

Five recent publications

1/ Mathieu C, Duval R, Cocaign A, Petit E, Bui LC, Haddad I, Vinh J, Etchebest C, Dupret JM, Rodrigues Lima F. An isozyme-specific redox switch in human brain glycogen phosphorylase modulates its allosteric activation by AMP. J Biol Chem. 2016 Sept 22. (Abstract) “Paper of the Week” of the Journal of Biological Chemistry

2/ Duval R, Xu X, Bui LC, Mathieu C, Petit E, Cariou K, Dodd RH, Dupret JM, Rodrigues-Lima F. Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens. Oncotarget. 2016 Feb 23;7(8):8688-99. (Abstract)

3/ George I, Naudin G, Boland S, Mornet S, Contremoulins V, Beugnon K, Martinon L, Lambert O, Baeza-Squiban A. Metallic oxide nanoparticle translocation across the human bronchial epithelial barrier. Nanoscale. 2015 Mar 14;7(10):4529-44. (Abstract)

4/ Guadagnini R, Moreau K, Hussain S, Marano F, Boland S. Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells. Nanotoxicology. 2015 May;9 Suppl 1:25-32. (Abstract)

5/ Vranic S, Boggetto N, Contremoulins V, Mornet S, Reinhardt N, Marano F, Baeza-Squiban A, Boland S. Deciphering the mechanisms of cellular uptake of engineered nanoparticles by accurate evaluation of internalization using imaging flow cytometry. Part Fibre Toxicol. 2013 Feb 6;10:2. (Abstract)

Pubmed referenced publications (since 2012)

Stone V, Miller MR, Clift MJ, Elder A, Mills NL, Møller P, Schins RP, Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TA, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR. Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge. Environ Health Perspect. 2016 Nov 4.

Mathieu C, Duval R, Cocaign A, Petit E, Bui LC, Haddad I, Vinh J, Etchebest C, Dupret JM, Rodrigues Lima F. An isozyme-specific redox switch in human brain glycogen phosphorylase modulates its allosteric activation by AMP. J Biol Chem. 2016 Sept 22

Mathieu C, de la Sierra-Gallay IL, Duval R, Xu X, Cocaign A, Léger T, Woffendin G, Camadro JM, Etchebest C, Haouz A, Dupret JM, Rodrigues-Lima F. Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE. J Biol Chem. 2016 Aug 26;291(35):18072-83.

Delaval M, Wohlleben W, Landsiedel R, Baeza-Squiban A, Boland S. Assessment of the oxidative potential of nanoparticles by the cytochrome c assay: assay improvement and development of a high-throughput method to predict the toxicity of nanoparticles. Arch Toxicol. 2016 Apr 8. [Epub ahead of print]

Sirri V, Jourdan N, Hernandez-Verdun D, Roussel P. Sharing of mitotic pre-ribosomal particles between daughter cells. J Cell Sci. 2016 Apr 15;129(8):1592-604.

Vranic S, Gosens I, Jacobsen NR, Jensen KA, Bokkers B, Kermanizadeh A, Stone V, Baeza-Squiban A, Cassee FR, Tran L, Boland S. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO(2) nanoparticles. Arch Toxicol. 2016 Feb 12. [Epub ahead of print]

Duval R, Xu X, Bui LC, Mathieu C, Petit E, Cariou K, Dodd RH, Dupret JM, Rodrigues-Lima F. Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens. Oncotarget. 2016 Feb 23;7(8):8688-99.

Bui LC, Tomkiewicz C, Pierre S, Chevallier A, Barouki R, Coumoul X. Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration. Toxicol Sci. 2016 Jan;149(1):158-66.

Lovera-Leroux M, Crobeddu B, Kassis N, Petit PX, Janel N, Baeza-Squiban A, Andreau K. The iron component of particulate matter is antiapoptotic: A clue to the development of lung cancer after exposure to atmospheric pollutants? Biochimie. 2015 Nov;118:195-206.

Messaoudi N, Gautier V, Dairou J, Mihoub M, Lelandais G, Bouloc P, Landoulsi A, Richarme G. Fermentation and alternative respiration compensate for NADH dehydrogenase deficiency in a prokaryotic model of DJ-1-associated Parkinsonism. Microbiology. 2015 Nov;161(11):2220-31.

Gemble S, Ahuja A, Buhagiar-Labarchède G, Onclercq-Delic R, Dairou J, Biard DS, Lambert S, Lopes M, Amor-Guéret M. Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA. PLoS Genet. 2015 Jul 16;11(7):e1005384.

Mihoub M, Abdallah J, Gontero B, Dairou J, Richarme G. The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal. Biochem Biophys Res Commun. 2015 Aug 7;463(4):1305-10.

Duval R, Fritsch L, Bui LC, Berthelet J, Guidez F, Mathieu C, Dupret JM, Chomienne C, Ait-Si-Ali S, Rodrigues-Lima F. An acetyltransferase assay for CREB-binding protein based on reverse phase-ultra-fast liquid chromatography of fluorescent histone H3 peptides. Anal Biochem. 2015 Oct 1;486:35-7.

Chan Ho Tong L, Dairou J, Bui LC, Bouillon J, Rodrigues-Lima F, Dupret JM, Silar P. Screen for soil fungi highly resistant to dichloroaniline uncovers mostly Fusarium species. Fungal Genet Biol. 2015 Aug;81:82-7.

Duval R, Bui LC, Berthelet J, Dairou J, Mathieu C, Guidez F, Dupret JM, Cools J, Chomienne C, Rodrigues-Lima F. A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2). Sci Rep. 2015 Jun 4;5:10750.

Cowie H, Magdolenova Z, Saunders M, Drlickova M, Correia Carreira S, Halamoda Kenzaoi B, Gombau L, Guadagnini R, Lorenzo Y, Walker L, Fjellsbø LM, Huk A, Rinna A, Tran L, Volkovova K, Boland S, Juillerat-Jeanneret L, Marano F, Collins AR, Dusinska M. Suitability of human and mammalian cells of different origin for the assessment of genotoxicity of metal and polymeric engineered nanoparticles. Nanotoxicology. 2015 May;9 Suppl 1:57-65.

Lavelle C, Busi F, Arluison V. Multiple approaches for the investigation of bacterial small regulatory RNAs self-assembly. Methods Mol Biol. 2015;1297:21-42.

George I, Naudin G, Boland S, Mornet S, Contremoulins V, Beugnon K, Martinon L, Lambert O, Baeza-Squiban A. Metallic oxide nanoparticle translocation across the human bronchial epithelial barrier. Nanoscale. 2015 Mar 14;7(10):4529-44.

Xu X, Li de la Sierra-Gallay I, Kubiak X, Duval R, Chaffotte AF, Dupret JM, Haouz A, Rodrigues-Lima F. Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A. Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):266-73.

Delaval M, Boland S, Solhonne B, Nicola MA, Mornet S, Baeza-Squiban A, Sallenave JM, Garcia-Verdugo I. Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia. Part Fibre Toxicol. 2015 Jan 21;12:1.

Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A. Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. J Biol Chem. 2015 Jan 16;290(3):1885-97.

Cayrol B, Fortas E, Martret C, Cech G, Kloska A, Caulet S, Barbet M, Trépout S, Marco S, Taghbalout A, Busi F, Wegrzyn G, Arluison V. Riboregulation of the bacterial actin-homolog MreB by DsrA small noncoding RNA. Integr Biol (Camb). 2015 Jan;7(1):128-41.

Mathieu C, Duval R, Xu X, Rodrigues-Lima F, Dupret JM. Effects of pesticide chemicals on the activity of metabolic enzymes: focus on thiocarbamates. Expert Opin Drug Metab Toxicol. 2015 Jan;11(1):81-94.

Gesbert G, Ramond E, Tros F, Dairou J, Frapy E, Barel M, Charbit A. Importance of branched-chain amino acid utilization in Francisella intracellular adaptation. Infect Immun. 2015 Jan;83(1):173-83.

Juricek L, Bui LC, Busi F, Pierre S, Guyot E, Lamouri A, Dupret JM, Barouki R, Coumoul X, Rodrigues-Lima F. Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites. Arch Toxicol. 2015 Dec;89(12):2403-12.

George I, Vranic S, Boland S, Courtois A, Baeza-Squiban A. Development of an in vitro model of human bronchial epithelial barrier to study nanoparticle translocation. Toxicol In Vitro. 2015 Feb;29(1):51-8.

Guadagnini R, Moreau K, Hussain S, Marano F, Boland S. Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells. Nanotoxicology. 2015 May;9 Suppl 1:25-32.

Guadagnini R, Halamoda Kenzaoui B, Walker L, Pojana G, Magdolenova Z, Bilanicova D, Saunders M, Juillerat-Jeanneret L, Marcomini A, Huk A, Dusinska M, Fjellsbø LM, Marano F, Boland S. Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests. Nanotoxicology. 2015 May;9 Suppl 1:13-24.

Cocaign A, Kubiak X, Xu X, Garnier G, Li de la Sierra-Gallay I, Chi-Bui L, Dairou J, Busi F, Abuhammad A, Haouz A, Dupret JM, Herrmann JL, Rodrigues-Lima F. Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition. Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):3066-79.

Boland S, Hussain S, Baeza-Squiban A. Carbon black and titanium dioxide nanoparticles induce distinct molecular mechanisms of toxicity. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Nov-Dec;6(6):641-52.

Baeza-Squiban A. [Physio-pathological impacts of inhaled nanoparticles]. Biol Aujourdhui. 2014;208(2):151-8.

Goix S, Lévêque T, Xiong TT, Schreck E, Baeza-Squiban A, Geret F, Uzu G, Austruy A, Dumat C. Environmental and health impacts of fine and ultrafine metallic particles: assessment of threat scores. Environ Res. 2014 Aug;133:185-94.

Laurieri N, Dairou J, Egleton JE, Stanley LA, Russell AJ, Dupret JM, Sim E, Rodrigues-Lima F. From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. PLoS One. 2014 May 13;9(5):e96370.

Ponti D, Bellenchi GC, Puca R, Bastianelli D, Maroder M, Ragona G, Roussel P, Thiry M, Mercola D, Calogero A. The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis. PLoS One. 2014 May 1;9(5):e96037.

Hussain S, Garantziotis S, Rodrigues-Lima F, Dupret JM, Baeza-Squiban A, Boland S. Intracellular signal modulation by nanomaterials. Adv Exp Med Biol. 2014;811:111-34.

Ramond E, Gesbert G, Rigard M, Dairou J, Dupuis M, Dubail I, Meibom K, Henry T, Barel M, Charbit A. Glutamate utilization couples oxidative stress defense and the tricarboxylic acid cycle in Francisella phagosomal escape. PLoS Pathog. 2014 Jan;10(1):e1003893.

Bui LC, Tabouy L, Busi F, Dupret JM, Janel N, Planque C, Delabar JM, Rodrigues-Lima F, Dairou J. A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase. Anal Biochem. 2014 Mar 15;449:172-8.

Xu X, Kubiak X, Dupret JM, Rodrigues-Lima F. Arylamine N-acetyltransferases: a structural perspective. Comments regarding the BJP paper by Zhou et al., 2013. Br J Pharmacol. 2014 Jan;171(1):279-80.

Xu X, Mathieu C, Boitard SE, Dairou J, Dupret JM, Agbulut O, Rodrigues-Lima F. Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: molecular, cellular and kinetic aspects. FEBS Lett. 2014 Jan 3;588(1):138-42.

Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, Magnan C, Migrenne S, Cruciani-Guglielmacci C, Cohen-Tannoudji J. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. Endocrinology. 2014 Feb;155(2):592-604.

Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui LC, Bats AS, Fournet JC, Fernandez-Salguero P, Aggerbeck M, Lotersztajn S, Barouki R, Coumoul X. Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin. Toxicol Sci. 2014 Jan;137(1):114-24.

Medjkane S, Perichon M, Marsolier J, Dairou J, Weitzman JB. Theileria induces oxidative stress and HIF1α activation that are essential for host leukocyte transformation. Oncogene. 2014 Apr 3;33(14):1809-17.

Gourdain S, Dairou J, Denhez C, Bui LC, Rodrigues-Lima F, Janel N, Delabar JM, Cariou K, Dodd RH. Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity. J Med Chem. 2013 Dec 12;56(23):9569-85.

Moullé VS, Le Foll C, Philippe E, Kassis N, Rouch C, Marsollier N, Bui LC, Guissard C, Dairou J, Lorsignol A, Pénicaud L, Levin BE, Cruciani-Guglielmacci C, Magnan C. Fatty acid transporter CD36 mediates hypothalamic effect of fatty acids on food intake in rats. PLoS One. 2013 Sep 6;8(9):e74021.

Kubiak X, Li de la Sierra-Gallay I, Chaffotte AF, Pluvinage B, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F. Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad. J Biol Chem. 2013 Aug 2;288(31):22493-505.

Cocaign A, Bui LC, Silar P, Chan Ho Tong L, Busi F, Lamouri A, Mougin C, Rodrigues-Lima F, Dupret JM, Dairou J. Biotransformation of Trichoderma spp. and their tolerance to aromatic amines, a major class of pollutants. Appl Environ Microbiol. 2013 Aug;79(15):4719-26.

Laurieri N, Egleton JE, Varney A, Thinnes CC, Quevedo CE, Seden PT, Thompson S, Rodrigues-Lima F, Dairou J, Dupret JM, Russell AJ, Sim E. A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1. PLoS One. 2013 Aug 5;8(8):e70600.

Bui LC, Manaa A, Xu X, Duval R, Busi F, Dupret JM, Rodrigues-Lima F, Dairou J. Acrolein, an α,β-unsaturated aldehyde, irreversibly inhibits the acetylation of aromatic amine xenobiotics by human arylamine N-acetyltransferase 1. Drug Metab Dispos. 2013 Jul;41(7):1300-5.

Ripoll C, Dairou J, Stora S, Delabar JM, Janel N. Plasma nitrate levels are increased in adult Down syndrome patients. Biomarkers. 2013 Jun;18(4):373-4.

Kermanizadeh A, Vranic S, Boland S, Moreau K, Baeza-Squiban A, Gaiser BK, Andrzejczuk LA, Stone V. An in vitro assessment of panel of engineered nanomaterials using a human renal cell line: cytotoxicity, pro-inflammatory response, oxidative stress and genotoxicity. BMC Nephrol. 2013 Apr 25;14:96.

Val S, Liousse C, Doumbia el HT, Galy-Lacaux C, Cachier H, Marchand N, Badel A, Gardrat E, Sylvestre A, Baeza-Squiban A. Physico-chemical characterization of African urban aerosols (Bamako in Mali and Dakar in Senegal) and their toxic effects in human bronchial epithelial cells: description of a worrying situation. Part Fibre Toxicol. 2013 Apr 2;10:10.

Hussain S, Vanoirbeek JA, Haenen S, Haufroid V, Boland S, Marano F, Nemery B, Hoet PH. Prior lung inflammation impacts on body distribution of gold nanoparticles. Biomed Res Int. 2013;2013:923475.

Laureti L, Selva M, Dairou J, Matic I. Reduction of dNTP levels enhances DNA replication fidelity in vivo. DNA Repair (Amst). 2013 Apr 1;12(4):300-5.

Tlili A, Jacobs F, de Koning L, Mohamed S, Bui LC, Dairou J, Belin N, Ducros V, Dubois T, Paul JL, Delabar JM, De Geest B, Janel N. Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice. Biochim Biophys Acta. 2013 Jun;1832(6):718-28.

Vranic S, Boggetto N, Contremoulins V, Mornet S, Reinhardt N, Marano F, Baeza-Squiban A, Boland S. Deciphering the mechanisms of cellular uptake of engineered nanoparticles by accurate evaluation of internalization using imaging flow cytometry. Part Fibre Toxicol. 2013 Feb 6;10:2.

Chan JJ, Flatters D, Rodrigues-Lima F, Yan J, Thalassinos K, Katan M. Comparative analysis of interactions of RASSF1-10. Adv Biol Regul. 2013 May;53(2):190-201.

Lemazurier E, Marano F. Predictive toxicology and ecotoxicology within the ANTIOPES network. Environ Sci Pollut Res Int. 2013 May;20(5):2689-91.

Kubiak X, Dairou J, Dupret JM, Rodrigues-Lima F. Crystal structure of arylamine N-acetyltransferases: insights into the mechanisms of action and substrate selectivity. Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):349-62.

Vranic S, Garcia-Verdugo I, Darnis C, Sallenave JM, Boggetto N, Marano F, Boland S, Baeza-Squiban A. Internalization of SiO₂ nanoparticles by alveolar macrophages and lung epithelial cells and its modulation by the lung surfactant substitute Curosurf. Environ Sci Pollut Res Int. 2013 May;20(5):2761-70.

Boublil L, Assémat E, Borot MC, Boland S, Martinon L, Sciare J, Baeza-Squiban A. Development of a repeated exposure protocol of human bronchial epithelium in vitro to study the long-term effects of atmospheric particles. Toxicol In Vitro. 2013 Mar;27(2):533-42.

Planque C, Dairou J, Noll C, Bui LC, Ripoll C, Guedj F, Delabar JM, Janel N. Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain. J Mol Neurosci. 2013 May;50(1):1-6.

Tomkiewicz C, Herry L, Bui LC, Métayer C, Bourdeloux M, Barouki R, Coumoul X. The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway. Oncogene. 2013 Apr 4;32(14):1811-20.

Joly-Amado A, Denis RG, Castel J, Lacombe A, Cansell C, Rouch C, Kassis N, Dairou J, Cani PD, Ventura-Clapier R, Prola A, Flamment M, Foufelle F, Magnan C, Luquet S. Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning. EMBO J. 2012 Nov 14;31(22):4276-88.

Val S, Belade E, George I, Boczkowski J, Baeza-Squiban A. Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin. Arch Toxicol. 2012 Dec;86(12):1851-9.

Hussain S, Smulders S, De Vooght V, Ectors B, Boland S, Marano F, Van Landuyt KL, Nemery B, Hoet PH, Vanoirbeek JA. Nano-titanium dioxide modulates the dermal sensitization potency of DNCB. Part Fibre Toxicol. 2012 May 23;9:15.

Ramgolam K, Hamel R, Rumelhard M, Marano F, Baeza-Squiban A. Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells. Arch Toxicol. 2012 Oct;86(10):1537-46.

Andreau K, Leroux M, Bouharrour A. Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity. Biochem Res Int. 2012;2012:493894.

Kubiak X, Dervins-Ravault D, Pluvinage B, Chaffotte AF, Gomez-Valero L, Dairou J, Busi F, Dupret JM, Buchrieser C, Rodrigues-Lima F. Characterization of an acetyltransferase that detoxifies aromatic chemicals in Legionella pneumophila. Biochem J. 2012 Jul 15;445(2):219-28.

Guantes R, Cayrol B, Busi F, Arluison V. Positive regulatory dynamics by a small noncoding RNA: speeding up responses under temperature stress. Mol Biosyst. 2012 Jun;8(6):1707-15.

Kubiak X, Pluvinage B, Li de la Sierra-Gallay I, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F. Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3]. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt 2):196-8.

Belade E, Armand L, Martinon L, Kheuang L, Fleury-Feith J, Baeza-Squiban A, Lanone S, Billon-Galland MA, Pairon JC, Boczkowski J. A comparative transmission electron microscopy study of titanium dioxide and carbon black nanoparticles uptake in human lung epithelial and fibroblast cell lines. Toxicol In Vitro. 2012 Feb;26(1):57-66.

Sliwa D, Dairou J, Camadro JM, Santos R. Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells. Biochem J. 2012 Feb 1;441(3):945-53.