Degenerative Processes, Stress and Aging

 

Selected publications

1/  Baloula V, Fructuoso M, Kassis N, Gueddouri D, Paul JL, Janel N. Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia. Redox Biol. 2018 Oct;19:200-209.

2/ Palandri A, Martin E, Russi M, Rera M, Tricoire H, Monnier V. Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich’s ataxia. Dis Model Mech. 2018 Jul 20;11(7).

3/ Sowa AS, Martin E, Martins IM, Schmidt J, Depping R, Weber JJ, Rother F, Hartmann E, Bader M, Riess O, Tricoire H, Schmidt T. Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2624-E2633

4/ Janel N, Alexopoulos P, Badel A, Lamari F, Camproux AC, Lagarde J, Simon S, Feraudet-Tarisse C, Lamourette P, Arbones M, Paul JL, Dubois B, Potier MC, Sarazin M, Delabar JM. Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease. Transl Psychiatry. 2017 Jun 20;7(6):e1154.

5/ de la Torre R, de Sola S, Hernandez G, Farré M, Pujol J, Rodriguez J, Espadaler JM, Langohr K, Cuenca-Royo A, Principe A, Xicota L, Janel N, Catuara-Solarz S, Sanchez-Benavides G, Bléhaut H, Dueñas-Espín I, Del Hoyo L, Benejam B, Blanco-Hinojo L, Videla S, Fitó M, Delabar JM, Dierssen M; TESDAD study group. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down’s syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016 Jul;15(8):801-10

 

Publications in peer-reviewed journals (since 2015)

Teseo S, Houot B, Yang K, Monnier V, Liu G, Tricoire H. G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model. Aging and disease, 10.14336/AD.2020.0714-1

Russi M, Martin E, D’Autréaux B, Tixier L, Tricoire H, Monnier V. A Drosophila model of Friedreich ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-acetyl cysteine. Hum Mol Genet. 2020 Oct 10;29(17):2831-2844. doi: 10.1093/hmg/ddaa170. PMID: 32744307.

Fructuoso M, Gu YC, Kassis N, de Lagran MM, Dierssen M, Janel N. Ethanol- Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. Mol Neurobiol. 2020 Jul;57(7):3195-3205. doi: 10.1007/s12035-020-01967-6. Epub 2020 Jun 5. PMID: 32504418.

Gu Y, Moroy G, Paul JL, Rebillat AS, Dierssen M, de la Torre R, Cieuta-Walti C, Dairou J, Janel N. Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup<sup>®</sup> Dietary Supplement: Role of Green Tea Catechins. Int J Mol Sci. 2020 Feb 19;21(4):1404. doi: 10.3390/ijms21041404. PMID: 32092951; PMCID: PMC7073110.

Dard R, Janel N, Vialard F. COVID-19 and Down’s syndrome: are we heading for a disaster? Eur J Hum Genet. 2020 Nov;28(11):1477-1478. doi: 10.1038/s41431-020-0696-7. Epub 2020 Jul 20. PMID: 32686759; PMCID: PMC7369541.

Postic G, Janel N, Tufféry P, Moroy G. An information gain-based approach for evaluating protein structure models. Comput Struct Biotechnol J. 2020;18:2228-2236. doi: 10.1016/j.csbj.2020.08.013. Epub 2020 Aug 18. PMID: 32837711; PMCID: PMC7431362.

Le Stunff H, Véret J, Kassis N, Denom J, Meneyrol K, Paul JL, Cruciani-Guglielmacci C, Magnan C, Janel N. Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration. Front Neurol. 2019 Jul 31;10:807.

London J, Ndiaye FK, Bui LC, Souchet B, Daubigney F, Magnan C, Luquet S, Dairou J, Janel N, Rouch C. Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain. Mol Neurobiol. 2019 Jun;56(6):3958-3971.

Movassat J, Delangre E, Liu J, Gu Y, Janel N. Hypothesis and Theory: Circulating Alzheimer’s-Related Biomarkers in Type 2 Diabetes. Insight From the Goto-Kakizaki Rat. Front Neurol. 2019 Jun 26;10:649.

Parizot E, Dard R, Janel N, Vialard F. Down syndrome and infertility: what support should we provide? J Assist Reprod Genet. 2019 Jun;36(6):1063-1067.

Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathol Commun. 2019 Mar 18;7(1):46.

Souchet B, Duchon A, Gu Y, Dairou J, Chevalier C, Daubigney F, Nalesso V, Créau N, Yu Y, Janel N, Herault Y, Delabar JM. Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models. Sci Rep. 2019 Mar 8;9(1):3914.

Latour A, Gu Y, Kassis N, Daubigney F, Colin C, Gausserès B, Middendorp S, Paul JL, Hindié V, Rain JC, Delabar JM, Yu E, Arbones M, Mallat M, Janel N. LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice. Mol Neurobiol. 2019 Feb;56(2):963-975.

London J, Rouch C, Bui LC, Assayag E, Souchet B, Daubigney F, Medjaoui H, Luquet S, Magnan C, Delabar JM, Dairou J, Janel N. Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues. Mol Neurobiol. 2018 May;55(5):3822-3831.

Artiushin G, Zhang SL, Tricoire H, Sehgal A. Endocytosis at the Drosophila blood-brain barrier as a function for sleep. Elife. 2018 Nov 26;7. pii: e43326.

Monnier V, Llorens JV, Navarro JA. Impact of Drosophila Models in the Study and Treatment of Friedreich’s Ataxia. Int J Mol Sci. 2018 Jul 7;19(7). pii: E1989.

Palandri A, Martin E, Russi M, Rera M, Tricoire H, Monnier V. Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich’s ataxia. Dis Model Mech. 2018 Jul 20;11(7).

Sowa AS, Martin E, Martins IM, Schmidt J, Depping R, Weber JJ, Rother F, Hartmann E, Bader M, Riess O, Tricoire H, Schmidt T. Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2624-E2633.

Baloula V, Fructuoso M, Kassis N, Gueddouri D, Paul JL, Janel N. Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia. Redox Biol. 2018 Oct;19:200-209.

Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M. Corrigendum to “Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome” [Free Radic. Biol. Med. 114 (2018) 122-130]. Free Radic Biol Med. 2018 Apr;118:150.

Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M. Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome. Free Radic Biol Med. 2018 Jan;114:122-130.

Janel N, Alexopoulos P, Badel A, Lamari F, Camproux AC, Lagarde J, Simon S, Feraudet-Tarisse C, Lamourette P, Arbones M, Paul JL, Dubois B, Potier MC, Sarazin M, Delabar JM. Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease. Transl Psychiatry. 2017 Jun 20;7(6):e1154.

Haddadi-Guemghar H, Tlili A, Dairou J, Paul JL, Madani K, Janel N. Effect of lyophilized prune extract on hyperhomocysteinemia in mice. Food Chem Toxicol. 2017 May;103:183-187.

Ragheb R, Chuyen A, Torres M, Defaye A, Seyres D, Kremmer L, Fernandez-Nunez N, Tricoire H, Rihet P, Nguyen C, Röder L, Perrin L. Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA. Sci Rep. 2017 Nov 24;7(1):16222.

de la Torre R, de Sola S, Hernandez G, Farré M, Pujol J, Rodriguez J, Espadaler JM, Langohr K, Cuenca-Royo A, Principe A, Xicota L, Janel N, Catuara-Solarz S, Sanchez-Benavides G, Bléhaut H, Dueñas-Espín I, Del Hoyo L, Benejam B, Blanco-Hinojo L, Videla S, Fitó M, Delabar JM, Dierssen M; TESDAD study group. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down’s syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016 Jul;15(8):801-10.

Yefsah-Idres A, Benazzoug Y, Otman A, Latour A, Middendorp S, Janel N. Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats. Food Funct. 2016 Jun 15;7(6):2862-9.

Créau N, Cabet E, Daubigney F, Souchet B, Bennaï S, Delabar J. Specific age-related molecular alterations in the cerebellum of Down syndrome mouse models. Brain Res. 2016 Jun 10.

Ramambason C, Moroy G, Daubigney F, Paul JL, Janel N. Effect of cadmium administration in hyperhomocysteinemic mice due to cystathionine beta synthase deficiency. Exp Toxicol Pathol. 2016 Jun;68(6):365-70.

Renon M, Legrand B, Blanc E, Daubigney F, Bokobza C, Mortreux M, Paul JL, Delabar JM, Rouach H, Andreau K, Janel N. Impact of Dyrk1A level on alcohol metabolism. Biochim Biophys Acta. 2016 May 20;1862(9):1495-1503.

Dambroise E, Monnier L, Ruisheng L, Aguilaniu H, Joly JS, Tricoire H, Rera M. Two phases of aging separated by the Smurf transition as a public path to death. Sci Rep. 2016 Mar 22;6:23523.

Tricoire H, Rera M. A New, Discontinuous 2 Phases of Aging Model: Lessons from Drosophila melanogaster. PLoS One. 2015 Nov 3;10(11):e0141920.

Lovera-Leroux M, Crobeddu B, Kassis N, Petit PX, Janel N, Baeza-Squiban A, Andreau K. The iron component of particulate matter is antiapoptotic: A clue to the development of lung cancer after exposure to atmospheric pollutants? Biochimie. 2015 Nov;118:195-206.

Souchet B, Guedj F, Penke-Verdier Z, Daubigney F, Duchon A, Herault Y, Bizot JC, Janel N, Créau N, Delatour B, Delabar JM. Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models. Front Behav Neurosci. 2015 Oct 20;9:267.

Bartesaghi R, Haydar TF, Delabar JM, Dierssen M, Martínez-Cué C, Bianchi DW. New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. J Neurosci. 2015 Oct 14;35(41):13843-52.

Palandri A, L’hôte D, Cohen-Tannoudji J, Tricoire H, Monnier V. Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells. Hum Mol Genet. 2015 May 1;24(9):2615-26.

Heidari R, Monnier V, Martin E, Tricoire H. Methylene Blue Partially Rescues Heart Defects in a Drosophila Model of Huntington’s Disease. J Huntingtons Dis. 2015;4(2):173-86.

Kariyawasam D, Rachdi L, Carré A, Martin M, Houlier M, Janel N, Delabar JM, Scharfmann R, Polak M. DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome. Endocrinology. 2015 Mar;156(3):1171-80.

Bouleau S, Tricoire H. Drosophila models of Alzheimer’s disease: advances, limits, and perspectives. J Alzheimers Dis. 2015;45(4):1015-38.

Souchet B, Latour A, Gu Y, Daubigney F, Paul JL, Delabar JM, Janel N. Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise. J Mol Neurosci. 2015 Feb;55(2):318-23.

Seguin A, Monnier V, Palandri A, Bihel F, Rera M, Schmitt M, Camadro JM, Tricoire H, Lesuisse E. A Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency. Oxid Med Cell Longev. 2015;2015:565140.