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| WEDNESDAY, SEPTEMBER 1, 2010 |
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| Symposium A: NAT polymorphisms, diseases and evolution / NAT nomenclature |
| Chairs: José A.G. Agundez, Spain; David W. Hein, USA; Sotiria Boukouvala, Greece |
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2:00 pm
| | Opening and Welcome Addresses
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2:25 pm
| | José A.G. Agundez, Badajoz, Spain
Copy number variations in the human NAT1 and NAT2 genes
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2:45 pm
| | David W. Hein, Louisville, USA
A single nucleotide polymorphism identified in a genome-wide scan tags variation in the N-acetyltransferase 2 phenotype in populations of european background
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3:05 pm
| | Audrey Sabbagh, Paris, France
Evolutionary pharmacogenetics of the NAT gene family: contrasting histories of the acetylation polymorphism in human and non-human primates
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3:25 pm
| | Etienne Patin, Paris, France
Deciphering the complex evolutionary history of human arylamine N-acetyltransferase genes
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3:45 pm
| | Coffee Break
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4:15 pm
| | Philippe Silar, Paris, France
The evolution of arylamine N-acetyltransferases in fungi
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4:35 pm
| | Sotiria Boukouvala, Alexandroupolis, Greece
Comparative genomic survey, exon-intron annotation and phylogenetic analysis of NAT homologous sequences in archaea, protists, fungi, viruses and invertebrates
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4:55 pm
| | Eleni P. Karagianni, Alexandroupolis, Greece
Arylamine N-acetyltransferases in mycotoxigenic and related fungi of agricultural significance
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5:15 pm
| | David W. Hein, Louisville, USA
Current nomenclature of human arylamine N-acetyltransferases
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5:35 pm
| | Sotiria Boukouvala, Alexandroupolis, Greece
Current nomenclature of non-human arylamine N-acetyltransferases
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5:55 pm
| | NAT nomenclature discussion
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| THURSDAY, SEPTEMBER 2, 2010 |
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| Symposium B: NAT and aromatic amine metabolism / animal models of NAT |
| Chairs: David W. Hein, USA; Charlene McQueen, USA |
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9:05 am
| | David W. Hein, Louisville, USA
Associations between N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms (SNPs) and haplotypes with catalytic activity in cryopreserved human hepatocytes: recommendations for NAT2 genotyping
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9:25 am
| | Peter J. O’Brien, Toronto, Canada
The marked increase in 4-aminobiphenyl induced hepatocyte cytotoxicity using an inflammation/oxidative stress model that causes NAT inhibition
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9:45 am
| | Denis M. Grant, Toronto, Canada
Roles of DNA damage, mutation rates and inflammation in the gender- and strain- selective liver carcinogenecity of 4-aminobiphenyl in mice
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10:05 am
| | Mark A. Doll, Louisville, USA
Difference between human slow N-acetyltransferase-2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutagenesis
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10:25 am
| | Coffee Break
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10:55 am
| | Carmine S. Leggett, Louisville, USA
Construction and functional characterization of nucleotide excision repair-deficient SV40-transformed human fibroblasts expressing human CYP1A2 and NAT2 genetic variants
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11:20 am
| | Charlene A. McQueen, Auburn, USA
PPAR alpha regulated genes are activated in mice by exposure to hydrazine, a metabolite of isoniazid
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12:00 noon
| | Lunch
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| Symposium C: NAT expression and regulation |
| Chair: Rodney F. Minchin, Australia |
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2:00 pm
| | Keynote lecture: Robert Barouki, Paris, France
The long term cost of detoxication
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2:30 pm
| | Rodney F. Minchin, Brisbane St Lucia, Australia
Role of human N-acetyltransferase 1 in cell growth and invasion
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2:50 pm
| | Neville Butcher, Brisbane St Lucia, Australia
Epigenetic regulation of human N-acetyltransferase 1
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3:10 pm
| | Brunhilde Blömeke, Trier, Germany
NAT1 activity in human keratinocytes and immune cells: possible implications for adaptive immune responses to aromatic diamines
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3:30 pm
| | Lori M. Millner, Louisville, USA
Differences in arylamine-induced mutagenesis with N-acetyltransferase 1 alternative mRNA isoforms
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3:50 pm
| | Julien Dairou, Paris, France
Uncoupled reaction of N-acetylation and AcCoA hydrolysis: example of folate
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4:10 pm
| | Jutta Bonifas, Trier, Germany
Analysis of NAT1 expression and keratinocyte differentiation
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4:30 pm
| | Florent Busi, Paris, France
Cadmium alters the biotransformation of carcinogenic aromatic amines by arylamine N-acetyltransferases: molecular, cellular and in vivo studies
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4:50 pm
| | Coffee Break
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5:20 pm
| | Poster session
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| FRIDAY, SEPTEMBER 3, 2010 |
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| Symposium D: Structures and enzymatic functions of NAT |
| Chair: Denis M. Grant, Canada |
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9:05 am
| | Carston Wagner, Minneapolis, USA
Interactions of arylnitroso metabolites of arylamine carcinogens with NATs in cells
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9:25 am
| | Fernando Rodrigues-Lima, Paris, France
Crystal structure of Bacillus anthracis arylamine N-acetyltransferase in complex with CoA reveals unusual structural properties
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9:45 am
| | Nicola Laurieri, Oxford, UK
Optimization of isoenzyme-specific reagents: organic synthesis and biological characterisation of naphtoquinones as selective inhibitors of human N-acetyltransferase 1 (hNAT1) and mouse NAT2 (mNAT2)
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10:05 am
| | Elodie Sanfins, Paris, France
Effects of carbon black nanoparticles on the biotransformation of carcinogen aromatic amines by the human arylamine N-acetyltransferase 1
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10:25 am
| | Coffee Break
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| Symposium E: NAT in microorganisms |
| Chair: Edith Sim, UK |
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10:40 am
| | Edith Sim, Oxford, UK
A novel reductase in the arylamine N-transferase (nat) operon of Mycobacterium smegmatis
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11:00 am
| | Xavier Kubiak, Paris France
Molecular characterisation of the arylamine N-acetyltransferase from three clinical strains of Legionella pneumophila
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11:20 am
| | Areej M. Abuhammad, Oxford, UK
Structural studies of the mycobacterial arylamine N-acetyltransferases
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11:40 am
| | Jean-Marie Dupret, Paris, France
Arylamine N-acetyltransferases of fungi: a tool for bioremediation of contaminated soils
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12:00 noon
| | Conclusions and lunch
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