Communicated by the Computational Modeling of Protein-Ligand Interactions Team
Cytochrome P450 3A4 (CYP3A4) is an enzyme located in the human liver. It has an important detoxification role and it catalyzes the oxidation of numerous xenobiotics. Modeling the channels leading to the active site of CYP3A4 provides a better understanding of its multispecificity.
Benkaidali, L; André, F; Moroy, G; Tangour, B; Maurel, F ; Petitjean, M. Four major channels detected in the cytochrome P450 3A4 : a stop toward understanding its multispecificity. Int. J. Mol. Sci. 2019, 20, 987. doi : 10.3390/ijms20040987
Online access : https://www.mdpi.com/1422-0067/20/4/987