Degenerative Processes, Stress and Aging
Head: Hervé Tricoire (DR CNRS)
Our team is interested in the degenerative processes involved in the aging of the organism and in various degenerative pathologies in humans. Our main objective is to identify genetic mechanisms to modulate these processes and, on this basis, to identify potential therapeutic interventions. In these studies, we use invertebrate model organisms (Drosophila flies, Drosophila melanogaster) or mammals (mice, Mus musculus), as well as cellular approaches. The following three main themes are developed:
1) Analysis of the different phases involved in aging and the molecular processes underlying each phase (in collaboration with M. Rera).
2) The analysis of neurodegenerative and cardiac pathologies linked to triplet expansions (Polyglutamine Expansion Diseases – Huntington’s disease, SCA3 – and Freidreich’s Ataxia) and the search for new therapeutic strategies (PIs: E. Martin and V. Monnier).
3) Analysis of the implication of metabolic pathologies in neurodegenerative diseases for the search for biomarkers and new therapeutic strategies (PIs: N. Janel and S. Middendorp).
Complementary methodologies (genetics, genomics, transgenesis and functional and behavioral analysis, etc.) are used in these various projects which are developed with national collaborators through European programs.